北京市眼科研究所金子兵团队

Publications

学术论文

1. Homeostasis and dyshomeostasis of the retina.

Zhang CJ, Jin ZB*.

Current Medicine 2023 in press. DOI:10.1007/s44194-023-00021-6. Invited review
2. Conversion of Mouse Embryonic Fibroblasts into Neural Crest Cells and Functional Corneal Endothelia by Defined Small Molecules.

Pan SH#, Zhao N#, Feng X, Jie Y, Jin ZB*.

Science Advances 2021 Jun 4;7(23):eabg5749.
3. Human Embryonic Stem Cell-Derived Organoid Retinoblastoma Reveals a Cancerous Origin.

Liu H#, Zhang Y#, Zhang YY, Li YP, Hua ZQ, Zhang CJ, Wu KC, Yu F, Zhang Y, Su J*, Jin ZB*.

Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33628-33638. Featured by ResearchFeatures
4. Second Hit Impels Oncogenesis of Retinoblastoma in Patient-iPSC-derived Retinal Organoids: Direct Evidence for Knudson’s Theory.

Li YP, Wang YT, Wang W, Zhang X, Shen RJ, Jin K, Jin LW, Jin ZB*.

PNAS Nexus. 2022. pgac162
5. Functional Microglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ.

Gao ML#, Zhang X#, Han F, Xu J, Yu SJ, Jin K, Jin ZB*.

SCIENCE CHINA Life Sciences. 2022 Jun;65(6):1057-1071. Cover story. Highlight.
6. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.

Deng WL#, Gao ML#, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin ZB*.

Stem Cell Reports. 2018;10:1267-81. BEST OF 2018-2019
7. Stemming Retinal Regeneration with Pluripotent Stem Cells.

Jin ZB*, Gao ML, Deng WL, Wu KC, Sugita S, Mandai M, Takahashi M.

Progress in Retinal and Eye Research 2019;69:38-56. Invited review. Highly Cited Paper 2021 March 25
8. COCO Enhances The Efficiency of Photoreceptor Precursor Differentiation in Human Pluripotent Stem Cell-derived Retinal Organoids.

Pan D, Xia XX, Zhou H, Jin SQ, Lu YY, Liu H, Gao ML, Jin ZB*.

Stem Cell Research & Therapy 2020 Aug 24;11(1):366.
9. Bioenergetic Crosstalk Between Mesenchymal Stem Cells and Various Ocular Cells Through Intercellular Trafficking of Mitochondria.

Jiang D, Chen FX, Zhou H, Lu YY, Tan H, Yu SJ, Yuan J, Liu H, Meng W, Jin ZB*.

Theranostics 2020;10(16):7260-7272. Front Cover. Highly Cited Paper 2021 Sept 9
10. A Novel Bruch's Membrane-mimetic Electrospun Substrate Scaffold for Human Retinal Pigment Epithelium Cells.

Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M*, Jin ZB*.

Biomaterials. 2014;35:9777-88.
11. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China.

Zhang H#, Su B#, Jiao L#, Xu ZH, Zhang CJ, Nie J, Gao ML*, Zhang YV*, Jin ZB*.

Annals of Translational Medicine 2021 Feb;9(3):245.
12. Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells.

Zhang X, Jin ZB*.

Journal of Visualized Experiments. 2021;doi: 10.3791/62298.
13. Relationship Between Cone Loss and Microvasculature Change in Retinitis Pigmentosa.

Lin R, Shen M, Pan D, Xu SZ, Shen RJ, Shao Y, Shi C, Lu F*, Jin ZB*.

Invest Ophthalmol Vis Sci 2019 Nov 1;60(14):4520-4531.
14. Eyes on coronavirus.

Li YP#, Ma Y#, Wang N, Jin ZB*.

Stem Cell Research. 2021 Mar;51:102200.
15. Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish.

Zhang XH, Jin ZB*.

Histol Histopathol. 2021 Jan 22:18307.
16. Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation.

Li YP#, Liu H#, Jin ZB*.

Stem Cell Research 2020 Dec;49:102075.
17. Towards stem cell-based neuronal regeneration for glaucoma.

Hua ZQ, Liu H, Wang N, Jin ZB*.

Progress in Brain Research 2020;257:99-118.
18. The road to restore vision with photoreceptor regeneration.

Zhang CJ, Ma Y, Jin ZB*.

Experimental Eye Research 2021 Jan;202:108283.
19. Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling.

Jin ZB*, Okamoto S, Xiang P, Takahashi M.

Stem Cells Translational Medicine 2012 Jun;1(6):503-9.
20. Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.

Gao ML#, Lei XL#, Han F#, He KW, Jin SQ, Zhang YY, Jin ZB*.

Front Cell Dev Biol. 2020 Mar 6;8:128. eCollection 2020.
21. Reconstruct human retinoblastoma in vitro.

Zhang X, Jin ZB*.

Journal of Visualized Experiments. 2021;in press.
22. Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9.

Lv JN, Zhou GH, Chen X, Chen H, Wu KC, Xiang L, Lei XL, Zhang X, Wu RH, Jin ZB*.

Sci Rep. 2017 Feb 20;7:43062.
23. Generation of retinal cells from pluripotent stem cells.

Jin ZB, Takahashi M*.

Progress in Brain Research 2012;201:171-81.
24. Modeling Human Retinoblastoma Using Embryonic Stem Cell-Derived Retinal Organoids.

Liu H, Hua ZQ, Jin ZB*.

STAR Protocols 2021 Jun 18;2:100444.
25. Modeling Retinitis Pigmentosa Through Patient-Derived Retinal Organoids.

Li YP, Deng WL, Jin ZB*.

STAR Protocols 2021 Jun 18;2:100438.
26. Human Retinal Organoids as Models for Development and Diseases.

Zhang X, Wang W, Jin ZB*.

Cell Regeneration 2021 Nov 1;10(1):33.
27. 中国眼科领域干细胞再生医学现状及展望.

赵宁，金子兵*.

中国科学-生命科学 2022 in press.
28. MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation.

Zhang X, Zhang BW, Xiang L, Hui W, Alexander SAS, Zhou P, Dai ZY, Wang X, Xiong W, Zhang Y, Jin ZB*, Deng LW*.

iScience 2022 in press.
29. 从视网膜类器官到“视网膜器官”的思考.

许佳，金子兵*.

中国科学-生命科学 2022 in press.
30. Human retinal pigment epithelial cells.

Wang L, Cao J, Peng Y, Fu B, Jin Z, Hu Y, Wu W, Xiang AP, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A, Stacey G, Zhao T, Hao J.

Cell Prolif. 2021 Nov 12:e13153. STANDARD
31. Requirements for Human Induced Pluripotent Stem Cells.

Zhang Y, Wei J, Cao J, Zhang K, Peng Y, Deng H, Kang J, Pan G, Zhang Y, Fu B, Hu S, Na J, Liu Y, Wang L, Liang L, Zhu H, Zhang Y, Jin ZB, Hao J, Ma A, Zhao T, Yu J.

Cell Prolif. 2022 Jan 26.doi.org/10.1111/cpr.13182. STANDARD
32. Retinal Organoids over the Decade.

Yuan J, Jin ZB*.

Organoids. 2022 Apr 16.Book Chapter.
33. Stem cell-based therapy for myopic maculopathy: a new concept.

Ma Y, Li YP, Jin ZB*.

J Transl Genet Genom 2022;6:179-203.
34. Generation of Human Patient iPSC-derived Retinal Organoids to Model Retinitis Pigmentosa.

Ma, C, Jin, K, Jin ZB*.

J. Vis. Exp. 2022; 184, e64045.
35. An overview on applications of retinal organoid derivatives.

Chen H, Jin ZB*.

Yan Ke Xue Bao, 2022,37(4):255-270.
36. Monitoring function of microglia in retina and nerve system diseases.

Xu J, Jin ZB*.

Zhonghua Shiyan Yanke Zazhi, 2022,40(8): in press.

学术论文

1. Homeostasis and dyshomeostasis of the retina.

2. Conversion of Mouse Embryonic Fibroblasts into Neural Crest Cells and Functional Corneal Endothelia by Defined Small Molecules.

3. Human Embryonic Stem Cell-Derived Organoid Retinoblastoma Reveals a Cancerous Origin.

4. Second Hit Impels Oncogenesis of Retinoblastoma in Patient-iPSC-derived Retinal Organoids: Direct Evidence for Knudson’s Theory.

5. Functional Microglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ.

6. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.

7. Stemming Retinal Regeneration with Pluripotent Stem Cells.

8. COCO Enhances The Efficiency of Photoreceptor Precursor Differentiation in Human Pluripotent Stem Cell-derived Retinal Organoids.

9. Bioenergetic Crosstalk Between Mesenchymal Stem Cells and Various Ocular Cells Through Intercellular Trafficking of Mitochondria.

10. A Novel Bruch's Membrane-mimetic Electrospun Substrate Scaffold for Human Retinal Pigment Epithelium Cells.

11. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China.

12. Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells.

13. Relationship Between Cone Loss and Microvasculature Change in Retinitis Pigmentosa.

14. Eyes on coronavirus.

15. Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish.

16. Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation.

17. Towards stem cell-based neuronal regeneration for glaucoma.

18. The road to restore vision with photoreceptor regeneration.

19. Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling.

20. Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.

21. Reconstruct human retinoblastoma in vitro.

22. Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9.

23. Generation of retinal cells from pluripotent stem cells.

24. Modeling Human Retinoblastoma Using Embryonic Stem Cell-Derived Retinal Organoids.

25. Modeling Retinitis Pigmentosa Through Patient-Derived Retinal Organoids.

26. Human Retinal Organoids as Models for Development and Diseases.

27. 中国眼科领域干细胞再生医学现状及展望.

28. MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation.

29. 从视网膜类器官到“视网膜器官”的思考.

30. Human retinal pigment epithelial cells.

31. Requirements for Human Induced Pluripotent Stem Cells.

32. Retinal Organoids over the Decade.

33. Stem cell-based therapy for myopic maculopathy: a new concept.

34. Generation of Human Patient iPSC-derived Retinal Organoids to Model Retinitis Pigmentosa.

35. An overview on applications of retinal organoid derivatives.

36. Monitoring function of microglia in retina and nerve system diseases.