Dr. Zi-Bing Jin M.D., Ph.D. Professor of Ophthalmology & Visual Sciences,Vice president Beijing Tongren Hospital, Capital Medical UniversityE-mail：jinzb502@ccmu.edu.cn

Dr. Jin is the professor of Capital Medical University (CMU) and 7th director (2020-2023) of Beijing Institute of Ophthalmology, vice president (2022-now) of Beijing Tongren Hospital, CMU. He received 3-year resident training in Ophthalmology after obtain his M.D. (MBBS) from Wenzhou Medical College in 2000. Afterward, he obtained Ph.D degree from University of Miyazaki in 2007 and then worked for 2-year as a postdoctoral fellow (JSPS fellowship) and 2-year research scientist (FPR) at the RIKEN Center for Developmental Biology under Dr. Masayo Takahashi’s supervision before returning to Wenzhou Medical College (renamed as University in 2013) in 2011. Until the end of 2019, he was the professor and the dean of Graduate School of the WMU. In 2020, he relocated at the current position. He focuses on stem cell translational medicine and genetic mechanisms of ocular diseases. His team is dedicating to make efforts on elucidating the disease mechanisms of inherited retinal degeneration and children ocular disorders, translating laboratory technology to improve bedside outcome, and solving key basic problems together with top-tier retina specialists. He is also developing RPE/photoreceptor replacement therapy using induced pluripotent stem (iPS) cells and bio-degradable scaffolds. For the first time, he established RP/Rb patient-derived iPS cells and retinal organoids for disease modeling and cell replacement.
  • Current research
  • 1. Regeneration of the diseased retina, esp. the macula in mammalians and humans;
  • 1. Patient-iPSC-derived retinal organoids in dish for disease modeling study;
  • 2. Development of iPSC-based therapies for human retinal degeneration;
  • 3. Retinal health of inherited retinal dystrophy, pathological myopia.
  • Editorial memeber
  • Invest Ophthalmol Vis Sci, Experimental Eye Research, Ophthalmic Research, Asia-Pacific Journal of Ophthalmology
  • Ad Hoc Reviewer for journal
  • Ophthalmology, Progress in Retinal and Eye Research, British Journal of Ophthalmolgy, Asia-Pacific Journal of Ophthalmology, Clinical and Experimental Ophthalmology, Documenta Ophthalmologica, Trends in Molecular Medicine, Investigative Ophthalmology & Visual Science, American Journal of Human Genetics, Molecular Therapy, Human Mutation, Clinical Genetics, Cell Stem Cell, Stem Cell Reports, Human Molecular Genetics, Journal of Medical Genetics, Theranostics, Stem Cells, Stem Cell Translational Medicine, Journal of Cell Science, Communications Biology, Advances in Therapy, Human Genetics, Experimental Eye Research, Eye, Ophthalmic Genetics, Molecular Vision, Regenerative Medicine, Gene, Journal of Human Genetics, Journal of Neurogenetics, Biomaterials, Advanced Healthcare Materials, Acta Biochimica et Biophysica Sinica, BMC Medical Genetics, European Journal of Ophthalmology, Current Eye Research, Frontiers in Genetics, Journal of Ocular Pharmacology and Therapeutics, BMC Evolutionary Biology, Cellular and Molecular Life Sciences, Journal of Pediatric Genetics, DNA and Cell Biology, Frontiers in Cell and Developmental Biology, Cutaneous and Ocular Toxicology, Briefings in Functional Genomics, Molecular Diagnosis & Therapy (2021), npj Genomic Medicine, European Journal of Preventive Cardiology, Bulletin of the World Health Organization, The FASEB Journal, Protein & Cell
  • Ad Hoc Reviewer for grant
  • Fight for Sight Foundation (USA); French National Research Agency; Netherlands Organisation for Health Research and Development; Poland National Science Centre (Narodowe Centrum Nauki - NCN; http://www.ncn.gov.pl); National Natural Science Foundation of China; National Key Research & Development Program; RETINA FRANCE; Childhood Eye Cancer Trust (UK); Israel Science Foundation (ISF); Foundation Fighting Blindness (USA); Swiss National Science Foundation (SNSF); UK Research and Innovation (UKRI)
  • Academic activity
  • Member of Macula Society (USA); Asia-Pacific Academy of Ophthalmology, international advisory board; Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting Program Committee (AMPC) member, Genetic Cross Section (2016-2019, 2018-2019 Chair).
  • Selected publications
  • 1. Zhao N, Zhang CJ, Zhang X, Wang W, Jin K, Jin ZB*. Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function. npj Regenerative Medicine. 2024 Dec 27;9(1):42.
  • 2. Wang W, Zhang X, Zhao N, Xu ZH, Jin K, Jin ZB*. RNA fusion in human retinal development. eLife. 2024 Jan 2:13:e92523.
  • 3. Yuan J, Chen F, Jiang D, Xu Z, Zhang H, Jin ZB*. ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium. Theranostics. 2024 Sep 9;14(15):5762-5777. Cover story.
  • 4. Zhou R, Mawatari G, Cai XB, Shen RJ, Wang YH, Wang YT, Guo YM, Guo FY, Yuan J, Pan D*, Nao-i N*, Jin ZB*. CLEC3B Is A Novel Causative Gene for Macular-retinal Dystrophy. Genetics in Medicine. 2022 Jun;24(6):1249-1260.
  • 5. Gao ML#, Zhang X#, Han F, Xu J, Yu SJ, Jin K, Jin ZB*. Functional Microglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ. SCIENCE CHINA Life Sciences. 2022 Jun;65(6):1057-1071. Cover story, Research highlight.
  • 6. Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB*, He DZ*. Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Science Advances. 2022 Apr 8;8(14):eabk0942.
  • 7. Pan SH#, Zhao N#, Feng X, Jie Y, Jin ZB*. Conversion of mouse embryonic fibroblasts into neural crest cells and functional corneal endothelia by defined small molecules. Science Advances. 2021 Jun 4;7(23):eabg5749.
  • 8. Li YP, Wang YT, Wang W, Zhang X, Shen RJ, Jin K, Jin LW, Jin ZB*. Second Hit Impels Oncogenesis of Retinoblastoma in Patient-iPSC-derived Retinal Organoids: Direct Evidence for Knudson’s Theory. PNAS Nexus. 2022 Aug 17;1(4):pgac162.
  • 9. Liu H, Zhang Y, Zhang YY, Li YP, Hua ZQ, Zhang CJ, Wu KC, Yu F, Zhang Y, Su J, Jin ZB*. Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33628-33638.
  • 10. Lin Q, Lv JN, Wu KC, Zhang CJ, Liu Q, Jin ZB*. Generation of Nonhuman Primate Model of Cone Dysfunction through In Situ AAV-Mediated CNGB3 Ablation. Mol Ther Methods Clin Dev. 2020 Aug 8;18:869-879.
  • 11. Pan D, Xia XX, Zhou H, Jin SQ, Lu YY, Liu H, Gao ML, Jin ZB*. COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids. Stem Cell Res Ther. 2020 Aug 24;11(1):366.
  • 12. Jiang D, Chen FX, Zhou H, Lu YY, Tan H, Yu SJ, Yuan J, Liu H, Meng W, Jin ZB*. Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria. Theranostics. 2020 Jun 5;10(16):7260-7272. Cover story.
  • 13. Wu KC, Lv JN, Yang H, Yang FM, Lin R, Lin Q, Shen RJ, Wang JB, Duan WH, Hu M, Zhang J, He ZL, Jin ZB*. Nonhuman Primate Model of Oculocutaneous Albinism with TYR and OCA2 Mutations. Research (Wash D C). 2020 Mar 11;2020:1658678.
  • 14. Zhang CJ, Xiang L, Chen XJ, Wang XY, Wu KC, Zhang BW, Chen DF, Jin GH, Zhang H, Chen YC, Liu WQ, Li ML, Ma Y, Jin ZB*. Ablation of Mature miR-183 Leads to Retinal Dysfunction in Mice. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):12.
  • 15. Cai XB, Zheng YH, Chen DF, Zhou FY, Xia LQ, Wen XR, Yuan YM, Han F, Piao SY, Zhuang W, Lu F, Qu J, Yu AY, Jin ZB*. Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients. Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):4052-4062.
  • 16. Cai XB, Shen SR, Chen DF, Zhang Q, Jin ZB*. An overview of myopia genetics. Exp Eye Res. 2019 Nov;188:107778.
  • 17. Jin ZB*, Gao ML, Deng WL, Wu KC, Sugita S, Mandai M, Takahashi M. Stemming retinal regeneration with pluripotent stem cells. Prog Retin Eye Res. 2019 Mar;69:38-56.
  • 18. Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin ZB*. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports. 2018 Apr 10;10(4):1267-1281. BEST OF 2018-2019.
  • 19. Xiang L, Chen XJ, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB*. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6376-6381.
  • 20. Jin ZB*, Wu J, Huang XF, Feng CY, Cai XB, Mao JY, Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, Cheng XW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F, Qu J. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4219-4224.