Dr. Zi-Bing Jin M.D., Ph.D. Professor of Ophthalmology & Visual Sciences,Director Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityE-mail:jinzb502@ccmu.edu.cn

Dr. Jin is the professor of Capital Medical University (CMU) and director of Beijing Institute of Ophthalmology, vice president of Beijing Tongren Hospital, CMU. He received 3-year resident training in Ophthalmology after obtain his M.D. (MBBS) from Wenzhou Medical College in 2000. Afterward, he obtained Ph.D degree from University of Miyazaki in 2007 and then worked for 2-year as a postdoctoral fellow (JSPS fellowship) and 2-year research scientist (FPR) at the RIKEN Center for Developmental Biology under Dr. Masayo Takahashi’s supervision before returning to Wenzhou Medical College (renamed as University in 2013) in 2011. Until the end of 2019, he was the professor and the dean of Graduate School of the WMU. In 2020, he relocated at the current position. He focuses on stem cell translational medicine and genetic mechanisms of ocular diseases. His team is dedicating to make efforts on elucidating the disease mechanisms of inherited retinal degeneration and children ocular disorders, translating laboratory technology to improve bedside outcome, and solving key basic problems together with top-tier retina specialists. He is also developing RPE/photoreceptor replacement therapy using induced pluripotent stem (iPS) cells and bio-degradable scaffolds. For the first time, he established RP/Rb patient-derived iPS cells and retinal organoids for disease modeling and cell replacement.
  • Research interests
  • 1. Regeneration of the diseased retina, esp. the macula in mammalians and humans;
  • 2. Transdifferentiation of key ocular tissues from fibroblasts through small molecules;
  • 3. Patient-iPSC-derived retinal organoids in dish for disease modeling of retinitis pigmentosa/retinoblastoma and transplantation with gene correction;
  • 4. Genetic dissection of complex ocular diseases, e.g. children eye diseases, early-onset blindness.
  • Editor or Associate Editor
  • Experimental Eye Research, Ophthalmic Research, Ophthalmic Genetics
  • Review Editor
  • Frontiers in Cell and Developmental Biology (2016~)
  • Ad Hoc Reviewer for journal
  • Ophthalmology, Progress in Retinal and Eye Research, Trends in Molecular Medicine, IOVS, American Journal of Human Genetics, Molecular Therapy, Human Mutation, Clinical Genetics, Stem Cell Reports, Theranostics, Stem Cells, Stem Cell Translational Medicine, Journal of Cell Science, Communications Biology, Advances in Therapy, Human Genetics, Experimental Eye Research, Eye, Ophthalmic Genetics, Molecular Vision, Regenerative Medicine, Gene, Journal of Human Genetics, PLoS One, Scientific Reports, Journal of Neurogenetics, Biomaterials, Advanced Healthcare Materials, Acta Biochimica et Biophysica Sinica, BMC Medical Genetics, Bioscience Reports, European Journal of Ophthalmology, Current Eye Research, Frontiers in Genetics, Journal of Ocular Pharmacology and Therapeutics, BMC Evolutionary Biology, Cellular Physiology and Biochemistry, Cellular and Molecular Life Sciences, Journal of Pediatric Genetics, DNA and Cell Biology, Frontiers in Cell and Developmental Biology, Cutaneous and Ocular Toxicology, Briefings in Functional Genomics
  • Ad Hoc Reviewer for grant
  • Natural Science Foundation of China; Fight for Sight Foundation (USA); French National Research Agency; Netherlands Organisation for Health Research and Development; Poland National Science Centre (Narodowe Centrum Nauki - NCN; http://www.ncn.gov.pl)
  • Academic activity
  • Association of Research in Vision and Ophthalmology (ARVO) (https://www.arvo.org/) Annual Meeting Program Committee member, Genetic Cross Section (2016-2019, 2019 Chair).
  • Ocular Genetics & Epigenetics
  • 1. Jin ZB*#, Wu J#, Huang XF, Feng CY, Cai XB, Mao JY, Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, Cheng XW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F*, Qu J*. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017;114:4219-24.
  • 2. Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen JF, Huang CJ, Wu J, Lu F, Qu J*. SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nature Communications. 2014;5:3517.
  • 3. Jin ZB, Li Z, Liu Z, Jiang Y, Cai XB, Wu J*. Identification of de novo germline mutations and causal genes for sporadic diseases using trio-based whole-exome/genome sequencing. Biological Reviews 2018;93:1014-31. Invited review.
  • 4. Huang XF, Huang F, Wu KC, Wu J, Chen J, Pang CP, Lu F, Qu J, and Jin ZB*. Genotype-phenotype correlation and mutation spectrum in a large cohort of inherited retinal dystrophy patients revealed by next-generation sequencing. Genetics in Medicine. 2015;7:271-8. ESI Highly Cited Paper (2016~2017), Research Front.
  • 5. Ran X, Cai WJ, Huang XF, Liu Q, Lu F, Qu J, Wu J* and Jin ZB*. RetinoGenetics: A Comprehensive Mutation Database for Genes Related to Inherited Retinal Degeneration. Database (Oxford). 2014;2014.
  • 6. Huang X, Wu J, Lv J, Zhang X, Jin ZB*. Identification of false-negative mutations missed by next-generation sequencing in retinitis pigmentosa patients: a complementary approach to clinical genetic diagnostic testing. Genetics in Medicine. 2015;17:307-11.
  • 7. Huang XF#, Xiang L#, Cheng W, Cheng FF, He KW, Zhang BW, Zheng SS, Han RY, Zheng YH, Xu XT, Yu HY, Zhuang W, Leung YF, Jin ZB*. Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract. Experimental and Molecular Medicine. 2018;50:53. Highlight.
  • 8. Zhou GH, Ma Y, Li ML, Zhou XY, Mou H, Jin ZB*. ATP1A3 mutation as a candidate cause of autosomal dominant cone-rod dystrophy. Human Genetics 2020 May 21. doi: 10.1007/s00439-020-02182-y.
  • 9. Huang XF, Mao JY, Huang ZQ, Rao FQ, Cheng FF, Li FF, Wang QF, Jin ZB*. Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease. Invest Ophthalmol Vis Sci. 2017;58:424-429.
  • 10. Cai XB#, Wu KC#, Zhang X#, Lv JN, Jin GH, Xiang L, Chen J, Huang XF, Pan D, Lu B, Lu F, Qu J, Jin ZB*. Whole exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome. Clinical Genetics 2019;96:61-71. Highlight & Cover story.
  • 11. Huang XF#, Xiang L#, Fang XL, Liu WQ, Zhuang YY, Chen ZJ, Shen RJ, Cheng W, Han RY, Zheng SS, Chen XJ, Liu X, Jin ZB*. Functional characterization of CEP250 variant identified in non-syndromic retinitis pigmentosa. Human Mutation. 2019;40:1039-1045.
  • 12. Chen ZJ, Lin KH, Lee SH, Shen RJ, Feng ZK, Wang XF, Huang XF, Huang ZQ, Jin ZB*. Mutation Spectrum and Genotype-Phenotype Correlation of Inherited Retinal Dystrophy in Taiwan. Clinical and Experimental Ophthalmology 2020;48(4):486-499.
  • 13. Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH, Jin ZB*. Mutations in LRP5, FZD4, TSPAN12, NDP, ZNF408 or KIF11 genes account for 38.7% Chinese patients with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2623-2629.
  • 14. Lin R, Shen M, Pan D, Xu SZ, Shen RJ, Shao Y, Shi C, Lu F*, Jin ZB*. Relationship Between Cone Loss and Microvasculature Change in Retinitis Pigmentosa. Invest Ophthalmol Vis Sci 2019 Nov 1;60(14):4520-4531.
  • 15. Cai XB, Zheng YH, Chen DF, Zhou FY, Xia LQ, Wen XR, Yuan YM, Han F, Piao SY, Zhuang W, Lu F, Qu J*, Yu AY*, Jin ZB*. Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients. Invest Ophthalmol Vis Sci 2019;60:4052-4062.
  • 16. Xiang L#, Chen XJ#, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB*. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017;114:6376-81.
  • 17. Zhang CJ, Xiang L, Wang XY, Chen XJ, Wu KC, Zhang BW, Chen DF, Jin GH, Chen YC, Liu WQ, Zhang H, Li ML, Ma Y, Jin ZB*. Ablation of mature miR-183 leads to retinal dysfunction in mice. Invest Ophthalmol Vis Sci 2020 Mar 9;61(3):12.
  • 18. Wu KC, Chen XJ, Jin GH, Wang XY, Yang DD, Li YP, Xiang L, Zhang BW, Zhou GH, Zhang CJ, Jin ZB*. Deletion of miR-182 leads to retinal dysfunction in mice. Invest Ophthalmol Vis Sci 2019;60:1265-1274.
  • 19. Sun LF, Chen XJ, Jin ZB*. Emerging roles of noncoding RNAs in retinal diseases. Clinical and Experimental Ophthalmology 2020 in press. Invited review.
  • 20. Chen XJ#, Zhang ZC#, Wang XY#, Zhao HQ, Li ML, Ma Y, Ji YY, Zhang CJ, Wu KC, Xiang L, Sun LF, Zhou M*, Jin ZB*. The circular RNome of developmental retina in mice. Molecular Therapy - Nucleic Acids 2019 Nov 26;19:339-349.
  • 21. Sun LF#, Zhang B#, Chen XJ#, Wang XY, Zhang BW, Ji YY, Wu KC, Wu JY*, Jin ZB*. Circular RNAs in human and vertebrate neural retinas. RNA Biology 2019 Jun;16(6):821-829. 
  • 22. Chen XJ, Li ML, Wang HY, Mou H, Wu Z, Wang XY, Zhang CJ, Xue X, Jin ZB*. Targeted knockout of the abundant retinal circRNA Cdr1as in mice. Frontiers in Cell and Developmental Biology 2020 in press.IF=5.216, 2区