Laboratory for Stem Cell and Retinal Regeneration, Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University
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Short biography

Dr. Jin received his M.D. (MBBS) from Wenzhou Medical College in 2000 and Ph.D from University of Miyazaki in 2007. He had worked for 2-year as a postdoctoral fellow (JSPS fellowship) and another 2-year research scientist (FPR) at the RIKEN Center for Developmental Biology under Dr. Masayo Takahashi before returning to Wenzhou Medical College (renamed as University) in 2011.

He is the full professor of Wenzhou Medical University (WMU) and director of the Stem Cell Research Institute, WMU. He is heading the Laboratory for Stem Cell and Retinal Regeneration as well as the Division of Ophthalmic Genetics, the Eye Hospital of WMU. Currently he is holding a concurrent post as the dean of the Graduate School of WMU.

He focuses on stem cell translational medicine and genetic mechanisms of ocular diseases. His lab is dedicating to make efforts on elucidating the disease mechanisms of inherited retinal degeneration and children ocular disorders, translating laboratory technology to improve bedside outcomes, and solving key basic problems together with retina specialists.

The major technologies in his laboratory include clinical genetics and new capture sequencing, genome-wide association study, molecular biology, pluripotent stem cell & differentiation, experimental animal models.

He has successfully discovered several new disease-causing genes and has run several independent GWAS studies in Wenzhou, esp. large-scale study in Tibetan and Han populations. He is also developing RPE replacement therapy using induced pluripotent stem (iPS) cells and bio-degradable scaffolds. For the first time, he established RP patient-derived iPS cell lines for in vitro disease modeling and drug test, opening the door of patient-specific iPS application in the field. He is keeping on the disease mechanism study using these cutting-edge, state-of-art tools in the laboratory.




Selected publications

1. Xiang L#, Chen XJ#, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB*. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6376-6381. IF=9.423, TOP期刊 1区

2. Jin ZB*#, Wu J#, Huang XF, Feng CY, Cai XB, Mao JY, Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, Cheng XW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F*, Qu J*. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4219-4224.1615970114. IF=9.423, TOP期刊 Q1

3. Yang J*#, Jin ZB*#, Chen J, Huang XF, Li XM, Liang YB, Mao JY, Chen X, Zheng Z, Bakshi A, Zheng DD, Zheng MQ, Wray NR, Visscher PM, Lu F*, Qu J*. Genetic signatures of high-altitude adaptation in Tibetans. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4189-4194. IF=9.423, TOP期刊 Q1 Science News "Mutations may reveal how Tibetans can live on world’s highest plateau"

4. Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen JF, Huang CJ, Wu J, Lu F, Qu J*. SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nature Communications. 2014;5:3517. IF= 11.329, TOP期刊 Q1

5. Huang XF, Huang F, Wu KC, Wu J, Chen J, Pang CP, Lu F, Qu J*, and Jin ZB*. Genotype-phenotype correlation and mutation spectrum in a large cohort of inherited retinal dystrophy patients revealed by next-generation sequencing. Genetics in Medicine. 2015;17:271-8. ESI Highly Cited Paper / Research Front. IF=7.710, TOP期刊 Q1

6. Jin ZB*, Okamoto S, Xiang P, Takahashi M. Integration-free iPS cells derived from retinitis pigmentosa patient for disease modeling. Stem Cells Translational Medicine, 2012;1:503-9. IF= 4.247, Q2 (Cover story)

7. Ran X#, Cai WJ#, Huang XF, Liu Q, Lu F, Qu J, Wu J* and Jin ZB*. RetinoGenetics: A Comprehensive Mutation Database for Genes Related to Inherited Retinal Degeneration. Database (Oxford). 2014 Jun 17;2014. IF= 2.627, Q2

8. Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M*, Jin ZB*. A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014;35:9777-88. IF= 8.387, TOP期刊 Q1

9. Zhang D, Li Y, Yao X, Wang H, Zhao L, Jiang H, Yao X, Zhang S, Ye C, Liu W, Cao H, Yu S, Wang Y, Li Q, Jiang J, Liu Y, Zhang L, Liu Y, Iwai N, Wang H, Li J, Li J, Li X, Jin ZB*, and Ying H*. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle. Cell Reports. 16 (3), 757-768. IF=7.87, TOP期刊 Q2

10. Huang XF, Wu J, Lv J, Zhang X, Jin ZB*. Identification of false-negative mutations missed by next-generation sequencing in retinitis pigmentosa patients: a complementary approach to clinical genetic diagnostic testing. Genetics in Medicine. 2015;17:307-11. IF= 7.710, TOP期刊 Q1

11. Huang XF, Mao JY, Huang ZQ, Rao FQ, Cheng FF, Li FF, Wang QF, Jin ZB*. Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):424-429. IF= 3.427, TOP期刊 Q2

12. Gao ML, Wu KC, Deng WL, Lei XL, Xiang L, Zhou GH, Feng CY, Cheng XW, Zhang CJ, Gu F, Wu RH*, Jin ZB*. Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):801-811. IF= 3.427, TOP期刊 Q2

13. Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH, Jin ZB*. Mutations in LRP5, FZD4, TSPAN12, NDP, ZNF408 or KIF11 genes account for 38.7% Chinese patients with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2623-2629. IF= 3.427, TOP期刊 2区


Kungfu novels (many yrs ago).

Laboratory for Stem Cell and Retinal Regeneration,
Division of Ophthalmic Genetics, The Eye Hospital
of Wenzhou Medical University, The State Key
Laboratory of Vision Science, China.
add.: No 270, West Xueyuan Rd., Wenzhou, 325027 China.
Tel/Fax: 86-577-88067926;
E-mail: rp[at]