Laboratory for Stem Cell and Retinal Regeneration, Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University
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Short biography

Mei-Ling Gao became a research scientist in 2014 after her Ph.D. training in Xiamen Unviersity. She studied Biological Engineering in University of Electronic Science and Technology where she won the scholarships and was granted the outstanding graduates in 2009. Afterwards she continued to study Marine Biology in Xiamen University and won full scholarships during her post-graduate study. She also studied Virology in the Third Institute of Oceanography, State Oceanic Administration as a joint training student from 2009 to 2014.

Research interests

1. In-dish disease modeling of retinitis pigmentosa

Patient’s iPS cells generated from peripheral blood mononuclear cells was used for retina differentiation under three-dimensional (3D) culture. This 3D retina derived from patient-iPSCs is an excellent model for mechanism investigation and drug screening.

2.Mechanism of retinal degeneration

Retinal degeneration (RD) is the leading cause of human vision loss. Innate immunity has been demonstrated as a key player in the pathogenesis of RD. She focues on the inflammation induced by TLR3 and the effect of this process using mouse model, explant retina and murine photoreceptor cell line.

Selected publications

1. Gao ML, Wu KC, Deng WL, Lei XL, Xiang L, Zhou GH, Feng CY, Cheng XW, Zhang CJ, Gu F, Wu RH*, Jin ZB*. Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):in press. IF= 3.427, TOP期刊 2区

2. Gao ML, Deng WL, Huang N, Wang YY, Lei XL, Xu ZQ, Hu DN, Cai JQ, Lu F*, Jin ZB*. Upregulation of GADD45α in light-damaged retinal pigment epithelial cells. Cell Death Discovery. 2016;2:16013.


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Laboratory for Stem Cell and Retinal Regeneration,
Division of Ophthalmic Genetics, The Eye Hospital
of Wenzhou Medical University, The State Key
Laboratory of Vision Science, China.
add.: No 270, West Xueyuan Rd., Wenzhou, 325027 China.
Tel/Fax: 86-577-88067926;
E-mail: rp[at]mail.eye.ac.cn