Laboratory for Stem Cell and Retinal Regeneration, Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University
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Peer reviewed publications

- 2018

1. Jin ZB, Li Z, Liu Z, Jiang Y, Cai XB, Wu J*. Identification of de novo germline mutations and causal genes for sporadic diseases using trio-based whole-exome/genome sequencing. Biological Reviews 2018 May;93(2):1014-1031. IF=11.615, TOP期刊 1区

2. Deng WL#, Gao ML#, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin ZB*. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Rep. 2018 Apr 10;10(4):1267-1281. IF=8.338, TOP期刊 1区

3. Huang XF, Chi W, Lin D, Dai ML, Wang YL, Yang YM, Jin ZB*, Wang Y*. Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. Curr Mol Med.. 2018 Mar 9;17(7):471-477.

4. Huang XF#, Xiang L#, Cheng W, Cheng FF, He KW, Zhang BW, Zheng SS, Han RY, Zheng YH, Xu XT, Yu HY, Zhuang W, Leung YF, Jin ZB.* Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract. Exp Mol Med. . 2018 Apr 27;50(4):53. Highlighted by the journal.

5. 杨极#, 王青锋#, 林蒙, 何凯文, 雷新兰, 高美玲, 潘登* and 金子兵*. 视网膜感光细胞对仿生电场刺激的非矢量应答 中国科学-生命科学 . 2018 doi: 10.1360/N052017-00243.

- 2017

1. Xiang L#, Chen XJ#, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB*. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6376-6381. IF=9.423, TOP期刊 1区

2. Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH, Jin ZB*. Mutations in LRP5, FZD4, TSPAN12, NDP, ZNF408 or KIF11 genes account for 38.7% Chinese patients with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2623-2629. IF= 3.427, TOP期刊 2区

3. Jin ZB*#, Wu J#, Huang XF, Feng CY, Cai XB, Mao JY, Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, Cheng XW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F*, Qu J*. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4219-4224.1615970114. IF=9.423, TOP期刊 1区

4. Yang J*#, Jin ZB*#, Chen J, Huang XF, Li XM, Liang YB, Mao JY, Chen X, Zheng Z, Bakshi A, Zheng DD, Zheng MQ, Wray NR, Visscher PM, Lu F*, Qu J*. Genetic signatures of high-altitude adaptation in Tibetans. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4189-4194. IF=9.423, TOP期刊 1区 Highlighted by Science News "Mutations may reveal how Tibetans can live on world’s highest plateau"

5.Huang XF, Mao JY, Huang ZQ, Rao FQ, Cheng FF, Li FF, Wang QF, Jin ZB*. Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):424-429. IF= 3.427, TOP期刊 2区

6.Gao ML, Wu KC, Deng WL, Lei XL, Xiang L, Zhou GH, Feng CY, Cheng XW, Zhang CJ, Gu F, Wu RH*, Jin ZB*. Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):801-811. IF= 3.427, TOP期刊 2区

7. Jiang Y, Li Z, Liu Z, Chen D, Wu W, Du Y, Ji L, Jin ZB, Li W*, Wu J*. mirDNMR: a gene-centered database of background de novo mutation rates in human. Nucleic Acids Res. 2017 Jan 4;45(D1):D796-D803. IF= 9.041, TOP期刊 1区

8. Jiao X, Li A, Jin ZB, Wang X, Iannaccone A, Traboulsi EI, Gorin MB, Simonelli F, Hejtmancik JF*. Identification and population history of CYP4V2 mutations in patients with Bietti crystalline corneoretinal dystrophy. Eur J Hum Genet. 2017 Apr;25(4):461-471. IF= 4.580 , 2区

9. Lv JN, Zhou GH, Chen X, Chen H, Wu KC, Xiang L, Lei XL, Zhang X, Wu RH, Jin ZB*. Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9. Sci Rep. 2017 Feb 20;7:43062. IF=5.228, 2区

10. Veleri S, Nellissery J, Mishra B, Manjunath SH, Brooks MJ, Dong L, Nagashima K, Qian H, Gao C, Sergeev YV, Huang XF, Qu J, Lu F, Cideciyan AV, Li T, Jin ZB, Fariss RN, Ratnapriya R, Jacobson SG, Swaroop A*. REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is critical for rod photoreceptor function and survival. Hum Mol Genet. 2017 Mar 23; IF=5.985, TOP期刊2区

11. Feng CY#, Huang XQ#, Cheng XW, Wu RH, Lu F, Jin ZB*. Mutational screening of SLC39A5, LEPREL1 and LRPAP1 in a cohort of 187 high myopia patients. Sci Rep. 2017 Apr 25;7(1):1120. IF=5.228, 2区

12. Jin ZB*. Whole Genome Sequencing in Genetic Eye Diseases. Chapter In book: Advances in Vision Research, Volume I, 2017 Jan;pp.21-29. Springer nature.

13. Huang XF, Huang ZQ, Fang XL, Chen ZJ, Cheng W, Jin ZB*. Retinal miRNAs variations in a large cohort of inherited retinal disease. Ophthalmic Genet. 2017 Jul 13:1-5. IF=1.2777, 4区

14. Benyamin B, He J, Zhao Q, Gratten J, Garton F, Leo PJ, Liu Z, Mangelsdorf M, Al-Chalabi A, Anderson L, Butler TJ, Chen L, Chen XD, Cremin K, Deng HW, Devine M, Edson J, Fifita JA, Furlong S, Han YY, Harris J, Henders AK, Jeffree RL, Jin ZB, Li Z, Li T, Li M, Lin Y, Liu X, Marshall M, McCann EP, Mowry BJ, Ngo ST, Pamphlett R, Ran S, Reutens DC, Rowe DB, Sachdev P, Shah S, Song S, Tan LJ, Tang L, van den Berg LH, van Rheenen W, Veldink JH, Wallace RH, Wheeler L, Williams KL, Wu J, Wu X, Yang J, Yue W, Zhang ZH, Zhang D, Noakes PG, Blair IP, Henderson RD, McCombe PA, Visscher PM, Xu H, Bartlett PF, Brown MA, Wray NR*, Fan D*. Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nat Commun. 2017 Sep 20;8(1):611. IF=11.329, TOP期刊1区

15. Huang XF, Huang ZQ, Lin D, Dai ML, Wang QF, Chen ZJ, Jin ZB*, Wang Y*. Unraveling the genetic cause of a consanguineous family with unilateral coloboma and retinoschisis: expanding the phenotypic variability of RAX mutations. Sci Rep. 2017 Aug 22;7(1):9064.IF=5.228, 2区

- 2016

1.Zhang D, Li Y, Yao X, Wang H, Zhao L, Jiang H, Yao X, Zhang S, Ye C, Liu W, Cao H, Yu S, Wang Y, Li Q, Jiang J, Liu Y, Zhang L, Liu Y, Iwai N, Wang H, Li J, Li J, Li X, Jin ZB*, and Ying H*. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle. Cell Reports. 16 (3), 757-768. IF=7.87,TOP期刊 2区

2.Huang XF, Wang Y, Li FF, Lin D, Dai ML, Wang QF, Jin ZB*. CFHR2-rs2986127 as a genetic protective marker for acute anterior uveitis in Chinese patients. Journal of Gene Medicine. 2016 Jun 16. doi: 10.1002/jgm.2890. IF=3.246,3区

3.Zhao H, Huang XF, Zheng ZL, Deng WL, Lei XL, Xing DJ, Ye L, Xu SZ, Chen J, Zhang F, Yu XP, Jin ZB*. Molecular genetic analysis of patients with sporadic and X-linked infantile nystagmus. BMJ Open. 2016 Apr 1;6(4):e010649. IF=2.562,3区

4.Wang QF, Huang XF, Zheng ZL, Dai ML, Cai WJ, Yang MM, Jin ZB, Wang YQ*. Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population. Eye (Lond). 2016. doi: 10.1038/eye.2016.146. IF=2.213,3区

5.Gao ML, Deng WL, Huang N, Wang YY, Lei XL, Xu ZQ, Hu DN, Cai JQ, Lu F*, Jin ZB*. Upregulation of GADD45α in light-damaged retinal pigment epithelial cells. Cell Death Discovery. 2016;2:16013.

6. Lin B, Cai XB, Zheng ZL, Huang XF, Liu XL, Qu J, Jin ZB*. Clinical and genetic analyses reveal novel pathogenic ABCA4 mutations in Stargardt disease families. Sci Rep. 2016 Oct 14;6:35414. IF=5.228, 2区

7. Cai XB, Huang XF, Tong Y, Lu QK*, Jin ZB*. Novel CHM mutations identified in Chinese families with Choroideremia. Sci Rep. 2016 Oct 14;6:35360. IF=5.228, 2区

8. Lu Y, Wang L, Li J, Wu B, Wu H, Luo Y, Jin ZB*, Shan X*. Molecular genetic analysis and phenotypic characteristics of a consanguineous family with glycogen storage disease type Ia. Mol Med Rep. 2016 Oct;14(4):3251-4. IF= 1.559, 4区

9. Huang XF, Lin D, Lin KH, Lee SH, Xia X, Yang YM, Zhu XF, Wang YL, Dai ML, Wang QF, Jin ZB, Wang Y*. Genotype-phenotype Association Study Reveals CFI-Rs13104777 to be a Protective Genetic Marker Against Acute Anterior Uveitis. Ocul Immunol Inflamm. 2016 Jul 5:1-6. IF= 2.481, 3区

10. Zhang L, Xiang L, Liu Y, Venkatraman P, Chong L, Cho J, Bonilla S, Jin ZB, Pang CP, Ko KM, Ma P, Zhang M, Leung YF*. A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PLoS One. 2016 Mar 1;11(3):e0149663. IF= 3.057, 3区

11. Li YF, Ou X, Xu S, Jin ZB, Iwai N, Lam KP*. Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology. 2016 Jun;148(2):140-9. IF= 4.078, 2区

- 2015

1.Huang XF, Wu J, Lv J, Zhang X, Jin ZB*. Identification of false-negative mutations missed by next-generation sequencing in retinitis pigmentosa patients: a complementary approach to clinical genetic diagnostic testing. Genetics in Medicine. 2015 Apr;17(4):307-11. IF= 7.710, TOP期刊 1区

2.Huang XF, Huang F, Wu KC, Wu J, Chen J, Pang CP, Lu F, Qu J, and Jin ZB*. Genotype-phenotype correlation and mutation spectrum in a large cohort of inherited retinal dystrophy patients revealed by next-generation sequencing. Genetics in Medicine. 2015;17(4):271-8. (Highly Cited Paper / Research Front in ESI) IF= 7.710, TOP期刊 1区

3. Li FF#, Huang XF#, Chen J, Yu XD, Zheng MQ, Lu F, Jin ZB*, Gan DK*. Identification of novel mutations by targeted exome sequencing and the genotype-phenotype assessment of patients with achromatopsia. Journal of Translational Medicine. 2015;13(1):334. IF= 3.694, 2区

4.Yang J#, Huang XF#, Tong Y, Jin ZB*. Targeted exome sequencing identified two novel truncation mutations in GPR98 causing Usher syndrome. Clinical and Experimental Ophthalmology. 2015 Oct 3. doi: 10.1111/ceo.12664. I= 2.546, 3区

5.Wu J#, Wang HT#, Huang XF, Lei XL, Lu QK*, Jin ZB*. Molecular screening of the LPCAT1 gene in patients with retinitis pigmentosa without defined mutations in known retinitis pigmentosa genes. Molecular Medicine Reports. 2015 Oct;12(4):5983-8. IF= 1.559, 4区

6. Yu P, Cui Y, Cai W, Wu H, Xiao X, Shao Q, Ma L, Guo S, Wu N, Jin ZB, Wang Y, Cai T*, Sun ZS, Qu J*. Lysosomal storage disease in the brain: mutations of the β-mannosidase gene identified in autosomal dominant nystagmus. Genetics in Medicine . 2015 Dec;17(12):971-9. IF= 7.710, TOP期刊 1区

- 2014

1.Xiang P#, Wu KC#, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB*. A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014;35:9777-88. IF= 8.387, TOP期刊 1区

2.Wang Y*#, Huang XF#, Yang MM, Cai WJ, Zheng MQ, Mao G, Pang CP, Jin ZB*. CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients. British Journal of Ophthalmology. 2014 Jul 29. pii: bjophthalmol-2014-305296. IF= 3.036, 2区

3.Wu J, Chen L, Tam OS, Huang XF, Pang CP*, Jin ZB*. Whole exome sequencing reveals genetic predisposition in a large family with retinitis pigmentosa. Biomed Research International. 2014;2014:302487. IF= 2.134, 3区

4.Ran X#, Cai WJ#, Huang XF, Liu Q, Lu F, Qu J, Wu J* and Jin ZB*. RetinoGenetics: A Comprehensive Mutation Database for Genes Related to Inherited Retinal Degeneration. Database (Oxford). 2014 Jun 17;2014. pii: bau047. doi: 10.1093/database/bau047. IF= 2.627, 2区

5.Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen JF, Huang CJ, Wu J, Lu F, Qu J*. SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nature Communications. 2014 Mar 27;5:3517. IF= 11.329, TOP期刊 1区

6.Huang XF#, Tu CS#, Xing DJ, Gan DK, Xu GZ* and Jin ZB*. R102W mutation in the RS1 gene responsible for retinoschisis and recurrent glaucoma. International Journal of Ophthalmology. 2014; 7:169-72. IF= 0.939, 4区

7.Xing DJ#, Zhang HX#, Huang N, Wu KC, Huang XF, Huang F, Tong Y, Pang CP, Qu J, Jin ZB*. Comprehensive Molecular Diagnosis of Bardet-Biedl Syndrome by High-throughput Targeted Exome Sequencing. PLoS One. 2014 Mar 7;9(3):e90599. doi: 10.1371/journal.pone.0090599. eCollection 2014. IF= 3.057, 3区

8.Zhang L, Shi W, Song L, Zhang X, Cheng L, Wang Y, Ge X, Li W, Zhang W, Min Q, Jin ZB, Qu J, Gu F*. A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family. Scientific Reports. 2014 Nov 6;4:6936. IF=5.228, 2区

9.Zhang Y, Ge X, Yang F, Zhang L, Zheng J, Tan X, Jin ZB, Qu J, Gu F*. Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells. Scientific Reports. 2014 Jun 23;4:5405. IF=5.228, 2区

10.Ge XL, Zhang Y, Wu Y, Lv J, Zhang W, Jin ZB, Qu J, Gu F*. Identification of a Novel GJA8 (Cx50) Point Mutation Causes Human Dominant Congenital Cataracts. Scientific Reports. 2014 Feb 18;4:4121. IF=5.228, 2区

11.Zhang X, Ge X, Shi W, Huang P, Min Q, Li M, Yu X, Wu Y, Zhao G, Tong Y, Jin ZB, Qu J, Gu F*. Molecular diagnosis of putative stargardt disease by capture next generation sequencing. PLoS One. 2014 Apr 24;9(4):e95528. IF= 3.057, 3区

12.Zhang X, Ge X, Yu Y, Zhang Y, Wu Y, Luan Y, Sun J, Qu J, Jin ZB, Gu F*. Identification of Three Novel Mutations in the FRMD7 Gene for X-linked Idiopathic Congenital Nystagmus. Scientific Reports. 2014 Jan 17;4:3745. IF=5.228, 2区

- 2013

1.Huang XF, Xiang P, Chen J, Xing DJ, Huang N, Min Q, Gu F, Tong Y, Pang CP, Qu J, Jin ZB*. Targeted Exome Sequencing Identified Novel USH2A Mutations in Usher Syndrome Families. PLoS One. 2013 May 30;8(5):e63832. IF= 3.057, 3区

2.Chen G, Shi X, Sun C, Li M, Zhou Q, Zhang C, Huang J, Qiu Y, Wen X, Zhang Y, Zhang Y, Yang S, Lu L, Zhang J, Yuan Q, Lu J, Xu G, Xue Y, Jin Z, Jiang C, Ying M, Liu X*. VEGF-mediated proliferation of human adipose tissue-derived stem cells. PLoS One. 2013 Oct 3;8(10):e73673. IF= 3.057, 3区

- 2012

1.Zhou WT, Ni YQ, Jin ZB, Zhang M, Wu JH, Zhu Y, Xu GZ, Gan DK*. Electrical Stimulation Ameliorates Light-induced Photoreceptor Degeneration In Vitro via Suppressing the Proinflammatory Effect of Microglia and Enhancing the Neurotrophic Potential of Müller Cells. Experimental Neurology, 2012; Dec;238(2):192-208. IF= 4.657, 2区

2.Jin ZB and Takahashi M*. Generation of retinal cells from pluripotent stem cells. Progress in Brain Research, 2012; 201:171-81. IF= 1.655, 3区

3.Huang J, McAlinden C, Wang Q, Jin ZB, Pesudovs K*. Embryonic stem-cell-derived retinal pigment epithelial cells for macular degeneration. The Lancet, 2012;378(9831):2050. Correspondence.

4.Jin ZB*, Okamoto S, Xiang P, Takahashi M. Integration-free iPS cells derived from retinitis pigmentosa patient for disease modeling. Stem Cells Translational Medicine, 2012;1:503-9. IF= 4.247, 2区 (Cover story)

- 2011

1.Gan DK, He CL, Shu HR, Hoffman MR, Jin ZB*. Novel RPGR-ORF15 Mutations in X-linked Retinitis Pigmentosa Patients. Neuroscience Letters, 2011, 500(1):16-9. IF= 2.10, 4区

2.Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, Iwata T, Takahashi M*. Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells. PLoS One. 2011; 6(2):e17084. IF= 3.057, 3区